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Hypertrophy of breast, Gigantomastia or macromastia is a rare connective tissue disorder. It has been qualified as enlargement of the breast exceeding 600 grams (21 oz), causing discomfort and stretching of the overlaying skin leading to ulceration. Also known as macromastia, it is the bilateral, benign progressive enlargement of the human breasts. Gigantomastia was first described in scientific literature in 1648. The condition may be caused by heightened sensitivity to the female hormones prolactin, estrogen and progesterone, and/or the presence of an unusually high quantity of these hormones in the woman’s bloodstream. Studies appear to show an abnormal reaction of the breast tissue to hormonal factors. In severe cases, a single breast of women with this disorder can weigh in excess of 20 pounds (9.1 kg) each. The largest recorded weight was 67 pounds (30 kg) per breast. It is most often related to pregnancy, estimated to occur 1 out of every 28,000 to 100,000 pregnancies worldwide.